Toxidromes

Toxidrome	Presentation	Vital Sign Changes	Causative Agents
Anticholinergic	Delirium, Flushed Skin, Dilated Pupils, Urinary Retention, Decreased Bowel Sounds, Memory Loss, Seizures Hot as a Hare, Dry as a Bone, Red as a Beet, Blind as a Bat	Tachycardia Hyperthermia Hypertension	Antihistamines Scopolamine Jimson Weed Angel Trumpet Benztropine CyclicAntidepressants Atropine
Cholinergic	Confusion, Weakness, Salivation, Lacrimation, Defecation, Emesis, Diaphoresis, Muscle Fasciculations, Miosis, Seizures	Bradycardia Hypothermia Tachypnea	Organophosphates Carbamates Mushrooms
Hallucinogenic	Disorientation, Hallucinations, Visual Illusions, Panic Reaction, Moist Skin, Hyperactive Bowel Sounds, Seizures	Tachycardia Tachypnea Hypertension	Amphetamines Cannabinoids Cocaine Phencyclidine (PCP)
Opiate/Narcotic	Altered Mental Status, Unresponsiveness, Miosis, Shock	Shallow Respirations Slow Respiratory Rate Bradycardia Hypothermia Hypotension	Opiates Propoxyphene Dextromethorphan
Sedative/Hypnotic	Coma, Stupor, Confusion, Sedation, Progressive Deterioration of CNS Function	Apnea	Barbiturates Benzodiazepines Ethanol Anticonvulsants
Sympathomimetic	Delusions, Paranoia, Diaphoresis, Piloerection, Mydriasis, Hyperreflexia, Seizures, Anxiety	Tachycardia Bradycardia (if pure alpha agonist) Hypertension	Cocaine Amphetamines Methamphetamine Phenylpropanolamine Ephedrine Pseudoephedrine Albuterol Ma huang