Toxidromes

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Toxidrome Presentation Vital Sign Changes Causative Agents

Anticholinergic

Delirium, Flushed Skin, Dilated Pupils, Urinary Retention, Decreased Bowel Sounds, Memory Loss, Seizures

Hot as a Hare, Dry as a Bone, Red as a Beet, Blind as a Bat

Tachycardia
Hyperthermia
Hypertension

Antihistamines
Scopolamine
Jimson Weed
Angel Trumpet
Benztropine
CyclicAntidepressants
Atropine

Cholinergic

Confusion, Weakness, Salivation, Lacrimation, Defecation, Emesis, Diaphoresis, Muscle Fasciculations, Miosis, Seizures

Bradycardia
Hypothermia
Tachypnea

Organophosphates
Carbamates
Mushrooms

Hallucinogenic

Disorientation, Hallucinations, Visual Illusions, Panic Reaction, Moist Skin, Hyperactive Bowel Sounds, Seizures

Tachycardia
Tachypnea
Hypertension

Amphetamines
Cannabinoids
Cocaine
Phencyclidine (PCP)

Opiate/Narcotic

Altered Mental Status, Unresponsiveness, Miosis, Shock

Shallow Respirations
Slow Respiratory Rate
Bradycardia
Hypothermia
Hypotension

Opiates
Propoxyphene
Dextromethorphan

Sedative/Hypnotic

Coma, Stupor, Confusion, Sedation, Progressive Deterioration of CNS Function

Apnea

Barbiturates
Benzodiazepines
Ethanol
Anticonvulsants

Sympathomimetic

Delusions, Paranoia, Diaphoresis, Piloerection, Mydriasis, Hyperreflexia, Seizures, Anxiety

Tachycardia
Bradycardia (if pure alpha agonist)
Hypertension

 

Cocaine
Amphetamines
Methamphetamine
Phenylpropanolamine
Ephedrine
Pseudoephedrine
Albuterol
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